Phenotype Image Detail

Image

Caption

The embryonic lethality of Cops6^{Gt(RRI087)Byg}/Cops6^{Gt(RRI087)Byg} mice can be partially rescued by concomitant loss of Trp53. Representative E9.5 embryos (with genotypes indicated) from intercross between male Cops6^{Gt(RRI087)Byg}/Cops6⁺ Trp53^tm1Glo/Trp53^tm1Glo and female Cops6^{Gt(RRI087)Byg}/Cops6⁺ Trp53^tm1Glo/Trp53⁺ mice are shown. Trp53^tm1Glo/Trp53^tm1Glo embryos cannot be detected at E9.5 but Cops6^{Gt(RRI087)Byg}/Cops6^{Gt(RRI087)Byg} Trp53^tm1Glo/Trp53^tm1Glo (Csn6-/-;p53-/-) embryos can be identified at this embryonic stage. Note that these embryos were less developed (panel E) or much smaller (panel F) when compared to other embryos.

Copyright

This image is from Zhao R, J Clin Invest 2011 Mar 1;121(3):851-65 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:172038

Associated Alleles

Symbol	Name
Cops6^Gt(RRI087)Byg	COP9 signalosome subunit 6; gene trap RRI087, BayGenomics
Trp53^tm1Glo	transformation related protein 53; targeted mutation 1, Guillermina Lozano

Associated Genotypes

Allelic Composition	Genetic Background
Cops6^Gt(RRI087)Byg/Cops6^Gt(RRI087)Byg Trp53^tm1Glo/Trp53^tm1Glo	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J