Phenotype Image Detail

Image

Caption

Raf1^tm1.1Bgn/Raf1⁺ (L613V/+) mice show cardiac hypertrophy with chamber dilatation. (A) Representative gross appearance and H&E-stained cross-sections (original magnification, 4; scale bars: 2 mm) of wild-type (WT) (n = 25) and mutant (n = 25) hearts at 8 weeks, as well as heart weight/BW ratio (HW/BW) of 4-month-old WT and mutant mice. (B) Cross-sections of cardiomyocytes (original magnification, 400; scale bars: 100 um). Cross-sectional area (numbers below) was measured in WGA-strained sections from 8 week-old mice (n = 5 samples per genotype, with 200 cells counted per sample using ImageJ). (C) Representative echocardiograms of hearts from 4-month-old mice. Arrows indicate LV diastolic dimension.

Copyright

This image is from Wu X, J Clin Invest 2011 Mar 1;121(3):1009-25 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:172034

Associated Alleles

Symbol	Name
Raf1^tm1.1Bgn	v-raf-leukemia viral oncogene 1; targeted mutation 1.1, Benjamin G Neel

Associated Genotypes

Allelic Composition	Genetic Background
Raf1^tm1.1Bgn/Raf1^+	involves: 129S6/SvEvTac * C57BL/6NCr