Phenotype Image Detail

Image

Caption

(C) Representative cecal pathology of E. histolytica-challenged but uninfected at day 3 animals showed nearly normal-looking morphology or a mild submucosal edema (top left and right). While infected wild-type (QQ) mice mainly exhibited submucosal edema and epithelial hyperplasia (bottom left), the infected Lepr^tm1.1Rll/Lepr^tm1.1Rll (R/R) cecum displayed marked mucosal destruction/ulceration and inflammation. E. histolytica trophozoites are indicated by arrows (bottom right and insert). Original magnification, x40; x 200 (inset).

Copyright

This image is from Duggal P, J Clin Invest 2011 Mar 1;121(3):1191-8 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:172012

Associated Alleles

Symbol	Name
Lepr^tm1.1Rll	leptin receptor; targeted mutation 1.1, Rudolph L Leibel

Associated Genotypes

Allelic Composition	Genetic Background
Lepr^tm1.1Rll/Lepr^tm1.1Rll	129P3/J-Lepr^tm1.1Rll