Phenotype Image Detail

Image

Caption

(A) Splenomegaly was observed in both Gt(ROSA)26Sor^{tm1(gp80,EGFP)Eces}/Gt(ROSA)26Sor⁺ Cd19^tm1(cre)Cgn/Cd19⁺ (left: ROSA26.vFLIP;CD19.cre mice Tg) and Gt(ROSA)26Sor^{tm1(gp80,EGFP)Eces}/Gt(ROSA)26Sor⁺ Ighg1^tm1(cre)Cgn/Ighg1⁺ mice (right: ROSA26.vFLIP;Cgamma1.cre mice Tg); at least 20 Tg and control anaimals were analyzed (error bars indicate SEM). (B) H&E, PNA, and BCL6 staining revealed the lack of germinal centers (GCs) in both Tg mouse lines. Abortive GCs in Peyer patches of Gt(ROSA)26Sor^{tm1(gp80,EGFP)Eces}/Gt(ROSA)26Sor⁺ Ighg1^tm1(cre)Cgn/Ighg1⁺ mice are shown (arrows). Scale bars: 200 um.

Copyright

This image is from Ballon G, J Clin Invest 2011 Mar 1;121(3):1141-53 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:172031

Associated Alleles

Symbol	Name
Cd19^tm1(cre)Cgn	CD19 antigen; targeted mutation 1, University of Cologne
Gt(ROSA)26Sor^tm1(gp80,EGFP)Eces	gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Ethel Cesarman
Ighg1^tm1(cre)Cgn	immunoglobulin heavy constant gamma 1 (G1m marker); targeted mutation 1, University of Cologne

Associated Genotypes

Allelic Composition	Genetic Background
Gt(ROSA)26Sor^tm1(gp80,EGFP)Eces/Gt(ROSA)26Sor^+ Cd19^tm1(cre)Cgn/Cd19^+	either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)
Gt(ROSA)26Sor^tm1(gp80,EGFP)Eces/Gt(ROSA)26Sor^+ Ighg1^tm1(cre)Cgn/Ighg1^+	either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)