Phenotype Image Detail

Image

Caption

(B) Testes from Kash5^{tm1b(KOMP)Wtsi}/Kash5^{tm1b(KOMP)Wtsi} (Kash5-null) animals are only ~25% of the size of those from wild-type (WT) littermates. (E) Hematoxylin and eosin (H&E) stained testis sections from WT and mutant littermates. The overall structure of the mutant testes is preserved with identifiable, albeit smaller, seminiferous tubules. At higher magnification (center panels) it is apparent that mutant seminiferous tubules lack sperm. WT testes have occasional TUNEL-positive nuclei (bottom panels). In mutant testes, widespread TUNEL staining is seen in ~30% of tubule cross sections.

Copyright

This image is from Horn HF, J Cell Biol 2013 Sep 30;202(7):1023-39, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:201813

Associated Alleles

Symbol	Name
Kash5^tm1b(KOMP)Wtsi	KASH domain containing 5; targeted mutation 1b, Wellcome Trust Sanger Institute

Associated Genotypes

Allelic Composition	Genetic Background
Kash5^tm1b(KOMP)Wtsi/Kash5^tm1b(KOMP)Wtsi	involves: C57BL/6J * C57BL/6N