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Caption | Telomeres associate with SUN1 in wild-type (WT) and Kash5tm1b(KOMP)Wtsi/Kash5tm1b(KOMP)Wtsi (Kash5-null) spermatocytes. (A) Spermatocyte spreads processed for telomere fluorescence in situ hybridization (Tel-FISH) and immunostained with anti-SUN1. In WT specimens 96.8 +/- 0.6% of telomeres are associated with SUN1 foci. In mutant spermatocytes the figure is lower at 55.8 +/- 2.0%. Nevertheless, telomeres can still associate with SUN1 in the absence of KASH5. (B) Spermatocyte spreads visualized by structured illumination microscopy (SIM). SUN1 exhibits the same ring-like structure as KASH5 at the tips of SCP3-positive axial strands in WT spermatocytes (insets). In mutant spermatocytes, SUN1 also localizes to the tips of SCP3-positive strands. However, the ring-like organization is replaced by seemingly unstructured foci (insets). | ||||
Copyright | This image is from Horn HF, J Cell Biol 2013 Sep 30;202(7):1023-39, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:201813 | ||||
Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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