Phenotype Image Detail

Image

Caption

Ccdc155 (KASH5) recruits dynein to nuclear envelope telomere attachment sites. (A) SUN1 foci and dynein intermediate chain (Dynein IC) colocalize in wild-type (WT) spermatocyte spreads. (B) In Kash5^{tm1b(KOMP)Wtsi}/Kash5^{tm1b(KOMP)Wtsi} (Kash5-null) spermatocytes, SUN1 foci have no associated dynein. In both A and B nuclei were co-stained with DAPI. Circles enclose clusters of SUN1 foci.

Copyright

This image is from Horn HF, J Cell Biol 2013 Sep 30;202(7):1023-39, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:201813

Associated Alleles

Symbol	Name
Kash5^tm1b(KOMP)Wtsi	KASH domain containing 5; targeted mutation 1b, Wellcome Trust Sanger Institute

Associated Genotypes

Allelic Composition	Genetic Background
Kash5^tm1b(KOMP)Wtsi/Kash5^tm1b(KOMP)Wtsi	involves: C57BL/6J * C57BL/6N