Phenotype Image Detail

Image

Caption

Infertility in Kash5^{tm1b(KOMP)Wtsi}/Kash5^{tm1b(KOMP)Wtsi} (Kash5-null) females. Sections of ovaries from both wild-type (WT) (A) and Kash5^{tm1b(KOMP)Wtsi}/Kash5^{tm1b(KOMP)Wtsi} (B) adult female littermates. Sections were stained with hematoxylin and eosin (H&E). Although WT ovaries display numerous follicles at various stages of development, such features are uniformly absent from the mutant samples. Clearly, Ccdc155 (KASH5) deficiency in females is associated with a profound gametogenesis defect.

Copyright

This image is from Horn HF, J Cell Biol 2013 Sep 30;202(7):1023-39, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:201813

Associated Alleles

Symbol	Name
Kash5^tm1b(KOMP)Wtsi	KASH domain containing 5; targeted mutation 1b, Wellcome Trust Sanger Institute

Associated Genotypes

Allelic Composition	Genetic Background
Kash5^tm1b(KOMP)Wtsi/Kash5^tm1b(KOMP)Wtsi	involves: C57BL/6J * C57BL/6N