Phenotype Image Detail

Image

Caption

3 (D-G) Morphology of two-week-old (P14) unskinned mouse heads (D), brains (E, F), and cerebellums (G), for wild-type (WT) and Cep120^tm1.2Blnw/Cep120^tm1.1Blnw Tg(Nes-cre)1Atp/0 (Cep120^-/fl;nes-cre) mice. The lines are in the same length for both WT and mutant, thus indicating the relative brain size or the extent of hydrocephalus in the mutant. Hematoxylin and eosin (H&E) staining of sagittal brain sections (E) confirms that the mutant ventricles of the brain are severely dilated. The boxed area in F is enlarged in (G). Cerebellums are outlined. The mutant cerebellum is significantly smaller (F).

Copyright

This image is from Wu C, PLoS One 2014;9(9):e107943, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:220629

Associated Alleles

Symbol	Name
Cep120^tm1.1Blnw	centrosomal protein 120; targeted mutation 1.1, Baolin Wang
Cep120^tm1.2Blnw	centrosomal protein 120; targeted mutation 1.2, Baolin Wang
Tg(Nes-cre)1Atp	transgene insertion 1, Andreas Trumpp

Associated Genotypes

Allelic Composition	Genetic Background
Cep120^tm1.1Blnw/Cep120^tm1.2Blnw Tg(Nes-cre)1Atp/0	involves: 129S6/SvEvTac * C57BL/6 * FVB/N