Phenotype Image Detail

Image

Caption

Loss of Cep120 results in failed expansion of granule neuron progenitors (GNPs), due to lack of a response to Hedgehog signaling. (A-F) Sagittal sections of P1, P7, and P14 wild-type and Cep120^tm1.1Blnw/Cep120^tm1.2Blnw Tg(Nes-cre)1Atp/0 (Cep120^f/-;nes-Cre) cerebellums were coimmunostained for Pax6 (red), Calb1 (green), and nuclei (DAPI, blue). Pax6 and Calb1 label GNPs and Purkinje cells, respectively. Framed areas in panels A-F are enlarged in A9-F9. EGL, external granule cell layer; PCL, Purkinje cell layer; ML, molecular layer; IGL, inner granule layer. Genotypes are shown to the left.

Copyright

This image is from Wu C, PLoS One 2014;9(9):e107943, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:220629

Associated Alleles

Symbol	Name
Cep120^tm1.1Blnw	centrosomal protein 120; targeted mutation 1.1, Baolin Wang
Cep120^tm1.2Blnw	centrosomal protein 120; targeted mutation 1.2, Baolin Wang
Tg(Nes-cre)1Atp	transgene insertion 1, Andreas Trumpp

Associated Genotypes

Allelic Composition	Genetic Background
Cep120^tm1.1Blnw/Cep120^tm1.2Blnw Tg(Nes-cre)1Atp/0	involves: 129S6/SvEvTac * C57BL/6 * FVB/N