Phenotype Image Detail

Image

Caption

Cep120 is required for centriole duplication and ciliogenesis. Wild-type (WT) and Cep120^tm1.2Blnw/Cep120^tm1.2Blnw (Cep120-/-) primary mouse embryonic fibroblasts (pMEFs) were coimmunostained for the indicated proteins. Most mouse mutant cells lacked either one or both centrioles, as indicated by gamma-tubulin staining. Staining for Cep164, Ta3, and Odf2 showed that the missing centriole was the mother centriole. Staining for Arl13b and acetylated alpha-tubulin indicated no cilia being formed in Cep120 mutant cells. Arrowheads point to the staining of gamma-tubulin (a centriole marker), the indicated proteins, or cilia.

Copyright

This image is from Wu C, PLoS One 2014;9(9):e107943, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:220629

Associated Alleles

Symbol	Name
Cep120^tm1.2Blnw	centrosomal protein 120; targeted mutation 1.2, Baolin Wang

Associated Genotypes

Allelic Composition	Genetic Background
Cep120^tm1.2Blnw/Cep120^tm1.2Blnw	involves: 129S6/SvEvTac * C57BL/6