Phenotype Image Detail

Image

Caption

Disrupted laminar organization of the cortex in Bicd2^tm1Hgrd/Bicd2^tm1Hgrd Tg(GFAP-cre)25Mes/0 mice. (e) Coronal LacZ/neutral red-stained sections of the cortex of Bicd2^tm1Hgrd/Bicd2^tm1Hgrd Tg(GFAP-cre)25Mes/0; the high magnification of the primary somatosensory cortex illustrates disrupted cortical laminar organization. Also note the thin corpus callosum (cc) and capsula externa (ce). (f) Immunofluorescence of NeuN and FoxP2 or Calbindin showing altered laminar distribution of FoxP2 and calbindin in the mutant cortex. FoxP2 that in control mice is present in lamina V and VI pyramidal neurons, in the mutant cortex is distributed in superficial lamina. Note the absence of a laminar organization of NeuN+ cells in the mutant cortex. Also note disorganized pyramidal cell layer in the CA1 of the mutant hippocampus (arrow). Scale bars: 1 mm (e), 200 um (e, f).

Copyright

This image is from Jaarsma D, Nat Commun 2014;5():3411, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:210236

Associated Alleles

Symbol	Name
Bicd2^tm1Hgrd	BICD cargo adaptor 2; targeted mutation 1, Casper Hoogenraad
Tg(GFAP-cre)25Mes	transgene insertion 25, Albee Messing

Associated Genotypes

Allelic Composition	Genetic Background
Bicd2^tm1Hgrd/Bicd2^tm1Hgrd Tg(GFAP-cre)25Mes/0	involves: C57BL/6 * FVB/N