Phenotype Image Detail

Image

Caption

Midline crossing defects in Srrm4^{tm1b(EUCOMM)Wtsi}/Srrm4^{tm1b(EUCOMM)Wtsi} (delta7-8/delta7-8) mice. (A) Negative grayscale images of immunofluorescence microscopy using an antibody to neurofilament on coronal sections of the rostral part of the corpus callosum of E18.5 embryos. Dashed lines with arrowheads show either the prototypical tracts of callosal axons in the wild-type (+/+) or the ectopic ventral projections in the homozygous mutant. Arrows indicate ectopic bundles in the heterozygous and homozygous mutants. Bar, 100 um.

Copyright

This image is from Quesnel-Vallieres M, Genes Dev 2015 Apr 1;29(7):746-59, and is displayed with the permission of Cold Spring Harbor Laboratory Press, who owns the Copyright. J:221584

Associated Alleles

Symbol	Name
Srrm4^tm1b(EUCOMM)Wtsi	serine/arginine repetitive matrix 4; targeted mutation 1b, Wellcome Trust Sanger Institute

Associated Genotypes

Allelic Composition	Genetic Background
Srrm4^tm1b(EUCOMM)Wtsi/Srrm4^tm1b(EUCOMM)Wtsi	involves: C57BL/6J * C57BL/6N