Phenotype Image Detail

Image

Caption

Bright field images of Sox10 in situ hybridization stained E9.5-10.5 (a) wild-type and (b) Ptch1^wig/Ptch1^wig (wiggable) embryos. Arrowheads and arrows, respectively point to ectopic Sox10 positive ganglia and agenesis or hypoplasia of the neural crest cell component of the cranial ganglia. Severe perturbations in cranial sensory ganglia formation are seen at E10.5. The trigeminal ganglion is lacking its neural crest cell derived proximal root (asterisk). Anterior to the trigeminal, multiple ectopic Sox10-positive ganglion-like condensations are seen. The facioacoustic/vestibulocochlear ganglia are abnormally shaped and persist as round hypoplastic ganglia. Caudal to the otocyst, the cranial ganglia are hypoplastic or absent (arrowhead). Rudimentary condensations corresponding to the glossopharyngeal and vagal may exist, but there is little evidence of formation of the caudal cranial ganglia. Abbreviations: f, facioacoustic/vestibule cochlear; g, glossopharyngeal; tg, trigeminal; v. vagal.

Copyright

This image is from Sandell LL, Genesis 2011 Apr;49(4):342-59, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:171522

Associated Alleles

Symbol	Name
Ptch1^wig	patched 1; wiggable

Associated Genotypes

Allelic Composition	Genetic Background
Ptch1^wig/Ptch1^wig	involves: 129S1/Sv * C57BL/6 * FVB/NJ