Phenotype Image Detail

Image

Caption

Bright field images of Sox10 in situ hybridization stained E9.5-10.5 (a) wild-type and (b) Aldh1a2^grim/Aldh1a2^grim (grimace) embryos. Arrowheads and arrows, respectively point to ectopic Sox10 positive ganglia and agenesis or hypoplasia of the neural crest cell component of the cranial ganglia. Mutant embryos exhibit severe defects in cranial ganglia development. The trigeminal ganglion is hypoplastic. The spatiotemporal reduction in Sox10 staining more caudally is consistent with agenesis of the facioacoustic/vestibulochoclear, glossopharyngeal, and vagal ganglia. The circular domains of Sox10 staining that remain coincide with small ectopic supernumerary otocysts. Abbreviations: f, facioacoustic/vestibule cochlear; g, glossopharyngeal; tg, trigeminal; v. vagal.

Copyright

This image is from Sandell LL, Genesis 2011 Apr;49(4):342-59, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:171522

Associated Alleles

Symbol	Name
Aldh1a2^grim	aldehyde dehydrogenase family 1, subfamily A2; grimace

Associated Genotypes

Allelic Composition	Genetic Background
Aldh1a2^grim/Aldh1a2^grim	involves: 129S1/Sv * C57BL/6 * FVB/NJ