Phenotype Image Detail

Image

Caption

Bright field images of Sox10 in situ hybridization stained E9.5-10.5 (a) wild-type and (b) pal/pal (palloncino) embryos. Arrowheads and arrows, respectively point to ectopic Sox10 positive ganglia and agenesis or hypoplasia of the neural crest cell component of the cranial ganglia. Apart from labeling of the otocyst and a small number of cells proximal to the first pharyngeal arch, the cranial region is largely devoid of Sox10 positive cells. The absence of Sox10 staining is consistent with perturbation of cranial neural crest cell development and extreme hypoplasia or agenesis of the trigeminal, facioacoustic/vestibulocochlear, glossopharyngeal, and vagal ganglia. Abbreviations: f, facioacoustic/vestibule cochlear; g, glossopharyngeal; tg, trigeminal; v. vagal.

Copyright

This image is from Sandell LL, Genesis 2011 Apr;49(4):342-59, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:171522

Associated Alleles

Symbol	Name
pal	palloncino

Associated Genotypes

Allelic Composition	Genetic Background
pal/pal	involves: 129S1/Sv * C57BL/6 * FVB/NJ