Phenotype Image Detail

Image

Caption

Bright and fluorescent images of Neurofilament of beta-tubulin innunostained E9.5-10.5 (a) wild-type and (b) Rdh10^trex/Rdh10^trex (trex) embryos. Arrowheads and arrows highlight agenesis or hypoplasia of neuronal differentiation in the midbrain and cranial ganglia. E10.5 mutant embryos exhibit hypoplastic trigeminal ganglia with truncated maxillary and mandibular branches. Tuj1 staining shows disorganization and agenesis of the facioacoustic/vestibulocochlear, glossopharyngeal, and vagal branches. Abbreviations: pl, plexus; f, facioacoustic/vestibule cochlear; g, glossopharyngeal; tg, trigeminal; v. vagal.

Copyright

This image is from Sandell LL, Genesis 2011 Apr;49(4):342-59, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:171522

Associated Alleles

Symbol	Name
Rdh10^trex	retinol dehydrogenase 10 (all-trans); trex

Associated Genotypes

Allelic Composition	Genetic Background
Rdh10^trex/Rdh10^trex	involves: 129S1/Sv * C57BL/6 * FVB/NJ