Phenotype Image Detail

Image

Caption

Bright and fluorescent images of Neurofilament of b-tubulin innunostained E9.5-10.5 (a) wild-type and (b) Ptch1^wig/Ptch1^wig (wiggable) embryos. Arrowheads and arrows highlight agenesis or hypoplasia of neuronal differentiation in the midbrain and cranial ganglia. Mutants show excessive neuronal differentiation in the hindbrain of the central nervous system and hypoplasia of the peripheral nervous system including defects in cranial ganglia branching (asterisks and arrowheads). Although the trigeminal, facial, and glossopharyngeal ganglia form, each appears smaller and disconnected from the neural tube. Abbreviations: pl, plexus; f, facioacoustic/vestibule cochlear; g, glossopharyngeal; tg, trigeminal; v. vagal.

Copyright

This image is from Sandell LL, Genesis 2011 Apr;49(4):342-59, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:171522

Associated Alleles

Symbol	Name
Ptch1^wig	patched 1; wiggable

Associated Genotypes

Allelic Composition	Genetic Background
Ptch1^wig/Ptch1^wig	involves: 129S1/Sv * C57BL/6 * FVB/NJ