Phenotype Image Detail

Image

Caption

Bright and fluorescent images of Neurofilament of beta-tubulin innunostained E9.5-10.5 (a) wild-type and (b) Kdr^orv/Kdr^orv (orvieto) embryos. Arrowheads and arrows highlight agenesis or hypoplasia of neuronal differentiation in the midbrain and cranial ganglia. Mutant embryos exhibit only a rudimentary neuronal differentiation within the cranial ganglia and a complete lack of neuronal differentiation within the midbrain (arrowheads). Mutants show only a single domain of neurofilament or beta-tubulin staining localized to the proximal end of the first pharyngeal arch probably representing a rudimentary trigeminal ganglion (arrowhead). There is little evidence of neuronal differentiation caudal to the trigeminal ganglion and no evidence of any axonal branching throughout the cranial region (arrows). In the central nervous system, the midbrain neuronal plexus is absent. Abbreviations: pl, plexus; f, facioacoustic/vestibule cochlear; g, glossopharyngeal; tg, trigeminal; v. vagal.

Copyright

This image is from Sandell LL, Genesis 2011 Apr;49(4):342-59, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:171522

Associated Alleles

Symbol	Name
Kdr^orv	kinase insert domain protein receptor; orvieto

Associated Genotypes

Allelic Composition	Genetic Background
Kdr^orv/Kdr^orv	involves: 129S1/Sv * C57BL/6 * FVB/NJ