Phenotype Image Detail

Image

Caption

Bright and fluorescent images of Neurofilament of beta-tubulin innunostained E9.5-10.5 (a) wild-type and (b) Med23^snouty/Med23^snouty (snouty) embryos. Arrowheads and arrows highlight agenesis or hypoplasia of neuronal differentiation in the midbrain and cranial ganglia. Mutants show only a single domain of neurofilament or beta-tubulin staining localized to the proximal end of the first pharyngeal arch probably representing a rudimentary trigeminal ganglion (arrowhead). There is little evidence of neuronal differentiation caudal to the trigeminal ganglion and no evidence of any axonal branching throughout the cranial region (arrows). Abbreviations: pl, plexus; f, facioacoustic/vestibule cochlear; g, glossopharyngeal; tg, trigeminal; v. vagal.

Copyright

This image is from Sandell LL, Genesis 2011 Apr;49(4):342-59, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:171522

Associated Alleles

Symbol	Name
Med23^snouty	mediator complex subunit 23; snouty

Associated Genotypes

Allelic Composition	Genetic Background
Med23^snouty/Med23^snouty	involves: 129S1/Sv * C57BL/6 * FVB/NJ