Phenotype Image Detail

Image

Caption

(D) Representative transmission electron micrographs of Mtor^tm1.1Gcon/Mtor^tm1.1Gcon A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/0 (KO) and wild-type (CTL) control hearts at 2 weeks after tamoxifen (TMX) administration. Mutant left ventricle (LV) myocardium presents with sarcomeric disarray and swollen mitochondria (arrowheads), whereas that of control has a normal ultrastructure. Original magnification: X2,000. (G) Representative transmission electron micrographs of CTL and mutant heart at 1 week after TMX administration. Autophagic bodies (arrowheads) were observed in the mutant myocardium. Original magnification: X4,000; inset, X2,000.

Copyright

This image is from Zhang D, J Clin Invest 2010 Aug 2;120(8):2805-16 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:163763

Associated Alleles

Symbol	Name
A1cf^Tg(Myh6-cre/Esr1*)1Jmk	APOBEC1 complementation factor; transgene insertion 1, Jeffery D Molkentin
Mtor^tm1.1Gcon	mechanistic target of rapamycin kinase; targeted mutation 1.1, Gianluigi Condorelli

Associated Genotypes

Allelic Composition	Genetic Background
Mtor^tm1.1Gcon/Mtor^tm1.1Gcon A1cf^Tg(Myh6-cre/Esr1*)1Jmk/A1cf^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N