Phenotype Image Detail

Image

Caption

Ccr6^tm1.1Jmf/Ccr6^tm1.1Jmf mice are resistant to IL23-induced acanthosis and dermal inflammation. Ears of wild-type (WT) and mutant mice were injected intradermally every other day for 16 days with 20ul PBS, either alone or containing 500 ng IL-23. (B) H&E-stained sections of PBS- or IL-23-injected ears from WT and mutant mice at day 15. k, hyperparakeratosis with intracorneal neutrophilic pustule; a, acanthosis; b, increased proliferative activity of basal layer epidermal keratinocytes; d, dermal mononuclear cell infiltrate; v, telangiectasia of dermal blood vessels. Sections are representative of 2 experiments.

Copyright

This image is from Hedrick MN, J Clin Invest 2009 Aug;119(8):2317-29 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:152716

Associated Alleles

Symbol	Name
Ccr6^tm1.1Jmf	C-C motif chemokine receptor 6; targeted mutation 1.1 Joshua M Farber

Associated Genotypes

Allelic Composition	Genetic Background
Ccr6^tm1.1Jmf/Ccr6^tm1.1Jmf	B6.129-Ccr6^tm1.1Jmf