Phenotype Image Detail

Image

Caption

H&E staining readily identifies immune infiltrates in the liver tissue from Pip4k2c^{tm1b(KOMP)Wtsi}/Pip4k2c^{tm1b(KOMP)Wtsi} (KO) mice. (Scale bars, 100 um.) The area of immune infiltrates of H&E-stained liver tissues was quantified using ImageJ software. Twenty-five mutant mice and 12 wild-type (WT) mice (four images per mouse) were examined. The results are presented as means SE of the means. (E) Immune infiltrates in liver tissue of the mutant mice are mostly T cells and B cells. The mutant liver sections of two animals (KO1 and KO2) were incubated with anti-CD3, anti-B220, and anti-Mac2 antibodies, respectively.

Copyright

This image is from Shim H, Proc Natl Acad Sci U S A 2016 Jul 5;113(27):7596-601. Copyright 2016 National Academy of Sciences, U.S.A. J:234283

Associated Alleles

Symbol	Name
Pip4k2c^tm1b(KOMP)Wtsi	phosphatidylinositol-5-phosphate 4-kinase, type II, gamma; targeted mutation 1b, Wellcome Trust Sanger Institute

Associated Genotypes

Allelic Composition	Genetic Background
Pip4k2c^tm1b(KOMP)Wtsi/Pip4k2c^tm1b(KOMP)Wtsi	involves: C57BL/6J * C57BL/6N