Phenotype Image Detail

Image

Caption

Impaired lateral branching in Klf6-deficient anterior prostates. Micro-dissected prostate from Klf6^tm1Fjs/Klf6^tm1Fjs Nkx3-1⁺/Nkx3-1⁺ (Klf^f/fNkx3.1^+/+; control)(A and C) and Klf6^tm1Fjs/Klf6^tm1Fjs Nkx3-1^tm3(cre)Mms/Nkx3-1⁺ (Klf^f/fNkx3.1^Cre/+; mutant)(B and D) mice were imaged using ex vivo micro-CT and three-dimensional images were reconstructed. Ductal tips (A and B) and branch points (C and D) were marked on the three-dimensional images, counted (n = 4 from each genotype) and plotted in bar graphs, respectively (E and F). The number of ductal tips and branch points sprouting out of the main ducts are significantly more in (A, C, and E) controls than (B, D, and F) mutant prostates. Statistical significance was calculated using Student's t test, and the bars represent mean +/- S.E. Bar, 1 mm for A-D.

Copyright

This image is from Leow CC, J Biol Chem 2009 Jul 31;284(31):21057-65 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:153183

Associated Alleles

Symbol	Name
Klf6^tm1Fjs	Kruppel-like transcription factor 6; targeted mutation 1, Frederic J de Sauvage
Nkx3-1^tm3(cre)Mms	NK3 homeobox 1; targeted mutation 3, Michael M Shen

Associated Genotypes

Allelic Composition	Genetic Background
Klf6^tm1Fjs/Klf6^tm1Fjs Nkx3-1^tm3(cre)Mms/Nkx3-1^+	involves: 129/Sv * C57BL/6