Phenotype Image Detail

Image

Caption

Histology of female mice fed a diet lacking delta-6 desaturase products (AIN93 diet) from weaning. Wild-type (WT), heterozygous, and Fads2^tm1Mtna/Fads2^tm1Mtna (homozygous) animals were euthanized at the manifestation of dermatitis in homozygotes (~21 weeks of age). No difference in histology was observed between wild-type (WT) and heterozygous mice. A: Ovary from WT mouse shows normal follicle maturation with multiple corpora lutea (arrows), whereas (B) ovary from homozygous mutant mouse is smaller and lacks mature corpora lutea. C: Thymus from WT mouse has normal cortex (c) and medulla (m), while (D) thymus from mutant mouse is small with severe cortical lymphocyte depletion. E: Spleen from WT mouse has normal white (w) and red (r) pulp. F: Spleen from mutant mouse is greatly enlarged (4.0x) due to expanded red pulp (r) whereas white pulp (w) is depleted. G: Ulcerative dermatitis (arrow) on head of mutant at necropsy. H: Ulceration of mutant skin with superficial exudation (e) and severe inflammation (i) of the dermis. H and E stain.

Copyright

This image is from Stroud CK, J Lipid Res 2009 Apr 7;50():1871-1880 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text is from JLR. J:153293

Associated Alleles

Symbol	Name
Fads2^tm1Mtna	fatty acid desaturase 2; targeted mutation 1, Manabu T Nakamura

Associated Genotypes

Allelic Composition	Genetic Background
Fads2^tm1Mtna/Fads2^tm1Mtna	involves: 129S6/SvEvTac * C57BL/6J