Phenotype Image Detail

Image

Caption

Histology of male mice fed when fed a diet lacking delta-6 desaturase products (AIN93 diet) from weaning. Wild-type (WT), heterozygous, and homozygous mutant animals were euthanized at the manifestation of dermatitis in homozygotes (~20 weeks of age). No difference in histology was observed between WT and heterozygous mice. Skin from a Fads2^tm1Mtna/Fads2^tm1Mtna mouse, (A) unaffected area, and (B) with ulcerative dermatitis (arrows). C: Seminiferous tubules in testis from WT mouse shows all stages of spermatogenesis including elongated spermatids (arrows) and spermatozoa (in lumen), while (D) testis from mutant mouse shows lack of elongated spermatids and spermatozoa. E: Epididymis from WT mouse contains viable spermatozoa (bracket), while (F) epididymis from mutant mouse contains sloughed round spermatids (smaller cells with round nuclei) and spermatocytes (larger cells with more dispersed chromatin). G: The intestine from a mutant mouse has an ulcer (bracket) at the ileocecal junction. H: Duodenum ulcer (arrow) in mutant with inflammation extending into the submucosa. No intestinal ulceration was found in WT and heterozygous animals. H and E stain.

Copyright

This image is from Stroud CK, J Lipid Res 2009 Apr 7;50():1871-1880 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text is from JLR. J:153293

Associated Alleles

Symbol	Name
Fads2^tm1Mtna	fatty acid desaturase 2; targeted mutation 1, Manabu T Nakamura

Associated Genotypes

Allelic Composition	Genetic Background
Fads2^tm1Mtna/Fads2^tm1Mtna	involves: 129S6/SvEvTac * C57BL/6J