Phenotype Image Detail

Image

Caption

Skeletal defects of Sh3pxd2b^nee/Sh3pxd2b^nee (nee) mice. X-ray imaging of mutant nee mice and wild-type (WT) littermate controls indicates the presence of multiple skeletal abnormalities in mutants. a, Adult mutants have a proportionally smaller skeleton in comparison to WT littermate controls. b, c Higher-magnification dorsal views of skulls showing a drastically reduced anterior-posterior length and slightly reduced width in mutants. d, e Higher-magnification view showing that hind legs of mutants are reduced in size but otherwise normal in anatomical appearance. Images from the same pair of 12-month-old female mice; littermate control is homozygous for the WT allele.

Copyright

This image is from Mao M, Mamm Genome 2009 Aug;20(8):462-75 and is displayed with the permission of Springer Science + Business Media, Inc., New York who owns the copyright. J:153369

Associated Alleles

Symbol	Name
Sh3pxd2b^nee	SH3 and PX domains 2B; nose eyes ear

Associated Genotypes

Allelic Composition	Genetic Background
Sh3pxd2b^nee/Sh3pxd2b^nee	B10.Cg-H2^h4 Sh3pxd2b^nee/GrsrJ