Phenotype Image Detail

Image

Caption

Coronal sections of Pkd1^tm2.2Bol/Pkd1^tm3.1Bol Tg(Nes-cre)1Kln/0 (Pkd1^Flox/deltaC;Nestin-Cre) brains (D, F, H) and the control brains (C, E, G) at P8 stained with hematoxylin-eosin show hydrocephalus with dilatation of the third ventricle (arrow). (I, J) Coronal sections of mutant (J) and control (I) brains at P10 show dilatation of the lateral ventricles (arrow). Scale bar C-J 1 mm.

Copyright

This image is from Wodarczyk C, PLoS One 2009;4(9):e7137, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:153606

Associated Alleles

Symbol	Name
Pkd1^tm2.2Bol	polycystin 1, transient receptor potential channel interacting; targeted mutation 2.2, Alessandra Boletta
Pkd1^tm3.1Bol	polycystin 1, transient receptor potential channel interacting; targeted mutation 3.1, Alessandra Boletta
Tg(Nes-cre)1Kln	transgene insertion 1, Rudiger Klein

Associated Genotypes

Allelic Composition	Genetic Background
Pkd1^tm2.2Bol/Pkd1^tm3.1Bol Tg(Nes-cre)1Kln/0	involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac * SJL