Phenotype Image Detail

Image

Caption

Pten^tm1Hwu/Pten^tm1Hwu Slc6a3^{tm1.1(cre)Bkmn}/Slc6a3⁺ mice show neuroprotective effects when treated with 6OHDA injection into the striatum. Animals were treated with a unilateral 6OHDA injection in the striatum, and perfused 4 weeks after the injection to analyze the effect of Pten ablation on the magnitude of the lesion. (A) The substantia nigra compacta (SNc) from control animals (n = 4) was markedly affected by the lesion as reflected by the significant loss of TH positive profiles in the ipsilateral side to the lesion as compared to the contralateral side. The dopaminergic neurons in mutant (n = 6) animals were largely spared after the lesion when compared to control animals. (B) The neuroprotective effects related to Pten ablation were observed at the level of the striatal axonal projections as well. Depletion of TH positive terminals in the striatum was reduced across the striatum in control animals, while axon terminal degeneration was much lower in mutant animals.

Copyright

This image is from Diaz-Ruiz O, PLoS One 2009;4(9):e7027, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:153622

Associated Alleles

Symbol	Name
Pten^tm1Hwu	phosphatase and tensin homolog; targeted mutation 1, Hong Wu
Slc6a3^tm1.1(cre)Bkmn	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; targeted mutation 1.1, Cristina M Backman

Associated Genotypes

Allelic Composition	Genetic Background
Pten^tm1Hwu/Pten^tm1Hwu Slc6a3^tm1.1(cre)Bkmn/Slc6a3^+	involves: 129S4/SvJae * C57BL/6