Phenotype Image Detail

Image

Caption

Del(15Krt7-Krt18)1Tmm/Del(15Krt7-Krt18)1Tmm (KO) embryos exhibit severe growth retardation and apoptosis, resulting from reduced protein biosynthesis, but maintain tissue integrity. (A-F) Semithin sections through wild-type (WT) (A-C) and mutant (D-F) embryos were stained with H&E. Note the tissue integrity in overview sections through complete E9.5 embryo in the WT (A) and the mutant (D) mice. Higher magnifications of the visceral yolk sac (B and E) and embryonic intestine (C and F) from WT and mutant embryos at E9.5 confirmed tissue integrity. (G-J) Whole mount photographs of WT (G and I) and mutant (H and J) embryos dissected from the yolk sac at E8.5 (G and H) and E9.5 (I and J). The mutant embryos were growth retarded by about 50%.

Copyright

This image is from Vijayaraj P, J Cell Biol 2009 Oct 19;187(2):175-84, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:153804

Associated Alleles

Symbol	Name
Del(15Krt7-Krt18)1Tmm	deletion, Chr 15, Thomas M Magin 1

Associated Genotypes

Allelic Composition	Genetic Background
Del(15Krt7-Krt18)1Tmm/Del(15Krt7-Krt18)1Tmm	involves: 129S7/SvEvBrd * C57BL/6