Phenotype Image Detail

Image

Caption

BH3 mutations in Bcl2l11 (Bim) ameliorate the degenerative disorders of Bcl2-deficient mice. (A) A 40-day-old Bcl2^tm1Dlo/Bcl2^tm1Dlo (Bcl-2^-/-) mouse and its wild-type (WT) littermate are shown above a 120-day-old Bcl2^tm1Dlo/Bcl2^tm1Dlo Bcl2l11^tm3.1Boui/Bcl2l11^tm3.1Boui (Bcl-2^-/-Bim^P/P) mouse and a WT mouse of that age. (B) Kidneys of Bcl2^tm1Dlo/Bcl2^tm1Dlo Bcl2l11^tm3.1Boui/Bcl2l11^tm3.1Boui mice show only mild signs of polycystic kidney disease (PKD) compared with Bcl2^tm1Dlo/Bcl2^tm1Dlo kidneys. (C) Normal spleen structure in Bcl2^tm1Dlo/Bcl2^tm1Dlo Bcl2l11^tm3.1Boui/Bcl2l11^tm3.1Boui mice versus the atrophied Bcl2^tm1Dlo/Bcl2^tm1Dlo spleen. Bars, 1 mm.

Copyright

This image is from Merino D, J Cell Biol 2009 Aug 10;186(3):355-62, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:153846

Associated Alleles

Symbol	Name
Bcl2l11^tm3.1Boui	BCL2 like 11; targeted mutation 3.1, Philippe Bouillet
Bcl2^tm1Dlo	B cell leukemia/lymphoma 2; targeted mutation 1, Dennis Y Loh

Associated Genotypes

Allelic Composition	Genetic Background
Bcl2^tm1Dlo/Bcl2^tm1Dlo	B6.129P2-Bcl2^tm1Dlo
Bcl2^tm1Dlo/Bcl2^tm1Dlo Bcl2l11^tm3.1Boui/Bcl2l11^tm3.1Boui	B6.Cg-Bcl2^tm1Dlo Bcl2l11^tm3.1Boui