Phenotype Image Detail

Image

Caption

Loss of germ cells in adult Cyp26b1^tm1Ptk/Cyp26b1^tm1Ptk Plekha5^{Tg(AMH-cre)1Flor}/0 (Cyp26b1^SC-/SC-) animals. 3-month-old wild-type (Cyp26b1^SC+/SC+) and mutant testes stained with hematoxylin and eosin (A and B) or antibodies to TRA98 (a germ cell marker, red in C and D), GATA-1 (a Sertoli cell marker, red in E and F) and 3bHSD (a Leydig cell marker, green in E and F). Note the decrease in the seminiferous tubule size in testes from mutant mice (F) compared to wild-type mice (E). Seminiferous tubules devoid of germ cells are indicated by asterisks. Bars, 20 um.

Copyright

This image is from Li H, PLoS One 2009;4(10):e7501, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:154048

Associated Alleles

Symbol	Name
Cyp26b1^tm1Ptk	cytochrome P450, family 26, subfamily b, polypeptide 1; targeted mutation 1, Martin Petkovich
Plekha5^Tg(AMH-cre)1Flor	pleckstrin homology domain containing, family A member 5; transgene insertion 1, Florian Guillou

Associated Genotypes

Allelic Composition	Genetic Background
Cyp26b1^tm1Ptk/Cyp26b1^tm1Ptk Plekha5^Tg(AMH-cre)1Flor/Plekha5^+	involves: 129S2/SvPas * C57BL/6 * SJL