Phenotype Image Detail

Image

Caption

Re-entry into mitotic cell cycle in embryonic Cyp26b1^tm1Ptk/Cyp26b1^tm1Ptk Plekha5^{Tg(AMH-cre)1Flor}/0 (Cyp26b1^SC-/SC-) male germ cells. Sections of testes from wild-type (Cyp26b1^SC+/SC+) (A, B, C, G, H, I) and mutant (D, E, F, J, K, L) littermates at E15.5 (A-F) and E16.5 (G-L) stained for the mitotic marker Ki67 (B, E, H, K, red) and the germ cell marker MVH (A, D, G, J, green). Overlays of images show Ki67 expressing germ cells are observed only in the mutant fetuses (F, arrowheads). Bar, 20 um.

Copyright

This image is from Li H, PLoS One 2009;4(10):e7501, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:154048

Associated Alleles

Symbol	Name
Cyp26b1^tm1Ptk	cytochrome P450, family 26, subfamily b, polypeptide 1; targeted mutation 1, Martin Petkovich
Plekha5^Tg(AMH-cre)1Flor	pleckstrin homology domain containing, family A member 5; transgene insertion 1, Florian Guillou

Associated Genotypes

Allelic Composition	Genetic Background
Cyp26b1^tm1Ptk/Cyp26b1^tm1Ptk Plekha5^Tg(AMH-cre)1Flor/Plekha5^+	involves: 129S2/SvPas * C57BL/6 * SJL