Phenotype Image Detail

Image

Caption

Malformations of the semicircular canals in Chd7^Whi/Chd7⁺, Tbx1^tm1Bld/Tbx1⁺, and Chd7^Whi/Chd7⁺ Tbx1^tm1Bld/Tbx1⁺ mice. (A) Paint-filled semicircular canals of the right ear of an E16.5 wild-type (WT) mouse showing normal canal morphology. (B) Tbx1^tm1Bld/Tbx1⁺ mouse displaying normal anterior (AC) and posterior canals (PC), but truncation of the lateral canal (arrowhead). (C) Chd7^Whi/Chd7⁺ mouse showing normal morphology of the anterior canal, truncation of the lateral canal, and some shortening of the posterior canal. (D) Chd7^Whi/Chd7⁺ Tbx1^tm1Bld/Tbx1⁺ mouse showing normal anterior canal, fusion of the posterior canal to the crus commune (CC), and absence of the lateral canal. Scale bar: 1 mm.

Copyright

This image is from Randall V, J Clin Invest 2009 Nov;119(11):3301-10 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:154590

Associated Alleles

Symbol	Name
Chd7^Whi	chromodomain helicase DNA binding protein 7; whirligig
Tbx1^tm1Bld	T-box 1; targeted mutation 1, Antonio Baldini

Associated Genotypes

Allelic Composition	Genetic Background
Tbx1^tm1Bld/Tbx1^+	B6.129S7-Tbx1^tm1Bld
Chd7^Whi/Chd7^+	B6.C3Fe-Chd7^Whi
Chd7^Whi/Chd7^+ Tbx1^tm1Bld/Tbx1^+	B6.Cg-Chd7^Whi Tbx1^tm1Bld