Phenotype Image Detail

Image

Caption

Postnatal lethality by P5, with arteriovenous malformations (AVMs) in the brain, lung, and GI tract of Acvrl1^tm2.1Spo/Acvrl1^tm2.1Spo Tg(Acvrl1-cre)L1Spo/0 mice. (A-E) Dissection microscopic views of vascular images of control (A and C) and mutant Acvrl1^tm2.1Spo/Acvrl1^tm2.1Spo Tg(Acvrl1-cre)L1Spo/0 mice (B, D, and E) P3 mouse brains with latex dye injected into the left ventricle of the heart. (D and E) Magnified views of blood vessels in the hippocampal area. (E) Asterisks indicate peculiar looping of vessels at the distal tips of arteries shunting to veins. A, artery; V, vein. (F-K) Vascular morphology of control (F, H, and J) and mutant (G, I, and K) P3 lungs. (F and G) Dissection microscopic view of pulmonary veins. Double-headed arrows indicate diameter of pulmonary veins. A dashed circle highlights the area of abnormal tangled vessels, and an arrow indicates looping of a dilated vessel (G). (H and I) Gross views of left lung after Evans blue dye injection via jugular veins. Note bumpy, dilated looping vessels in the mutant lungs (I). (J and K) Scanning electron microgram view of corrosion cast, showing lack of microvessels and presence of numerous dilated looping vessels (asterisks) in the mutant lungs (K). (L-Q) Gross views of small intestines of control (L, N, and P) and mutant (M, O, and Q) P3 mice. AV shunts and abnormal anastomosis was observed by latex dye (O) and corrosion cast (indicated by an arrow with asterisk; Q). Scale bars: 2 mm (A and B); 1 mm (C, D, H, I, and N-Q); 300 um (E); 500 um (F, G, L, and M).

Copyright

This image is from Park SO, J Clin Invest 2009 Nov;119(11):3487-96 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:154620

Associated Alleles

Symbol	Name
Acvrl1^tm2.1Spo	activin A receptor, type II-like 1; targeted mutation 2.1, S Paul Oh
Tg(Acvrl1-cre)L1Spo	transgene insertion L1, S Paul Oh

Associated Genotypes

Allelic Composition	Genetic Background
Acvrl1^tm2.1Spo/Acvrl1^tm2.1Spo Tg(Acvrl1-cre)L1Spo/0	involves: 129 * FVB