Phenotype Image Detail

Image

Caption

Lethality with hemorrhages in the lung and GI tract in Acvrl1^tm2.1Spo/Acvrl1^tm2.1Spo Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺ (mutant) mice. (A) Kaplan-Meier survival curve, showing lethality in mutant male and female adult mice. Female mice were more sensitive to Acvrl1 (Alk1) deletion than males. (B-D) Mutant mice displayed external signs of internal bleeding and anemia, such as pale paws (B), a low pO2 level (C), and darkened feces (D) by 8 days after tamoxifen (TM) injection. (E) Reduced hematocrit in the mutants 8 days after TM injection. Error bars in C and E indicate SD. (F-H) Superficial blood vessels in the small intestine of the mutant 8 day after TM injecting were visualized by latex dye. Formation of arteriovenous malformation (AVM) judged by the presence of latex dye in both arteries and veins was apparent in the areas of Peyer's patches (G). Scale bars: 4 mm (F); 2 mm (G and H). *P < 0.05; **P < 0.001.

Copyright

This image is from Park SO, J Clin Invest 2009 Nov;119(11):3487-96 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:154620

Associated Alleles

Symbol	Name
Acvrl1^tm2.1Spo	activin A receptor, type II-like 1; targeted mutation 2.1, S Paul Oh
Gt(ROSA)26Sor^tm1(cre/ERT)Nat	gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Jeremy Nathans

Associated Genotypes

Allelic Composition	Genetic Background
Acvrl1^tm2.1Spo/Acvrl1^tm2.1Spo Gt(ROSA)26Sor^tm1(cre/ERT)Nat/Gt(ROSA)26Sor^+	involves: 129 * 129S1/Sv * 129X1/SvJ