Phenotype Image Detail

Image

Caption

Hemorrhages and vascular malformation in the lungs and GI tract of tamoxifen (TM)-treated adult Acvrl1^tm2.1Spo/Acvrl1^tm2.1Spo Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺ (R26^CreER/+;Alk1^2f/2f) mice. A, B. Gross morphology of heart and lungs of control and mutant mice 8 days after TM-treatment. Note enlarged mutant heart and lungs and hemorrhagic spots in the mutant lungs (B). C, D. Pulmonary arteries are visualized by latex dye injected via right heart. Note enlarged arteries and reduced perfusion to distal microvessels in the mutant lungs. E, F. Pulmonary veins (and bronchial arteries) by latex dye injected via left ventricle and left atrium. Photograph of control and mutant lungs was taken side by side. Mutant veins were significantly enlarged and showed roughness along the vessels indicating high permeability. G, H. Gross morphology of GI tract. Mutant guts were purplish and displayed signs of hemorrhages. A, appendix. I-L. Blood vessels of Peyer's patches in the ilium (I and J) and appendix (K and L) of control (I and K) and mutant (J and L) mice were visualized by the latex dye injection. Dotted circles indicate the represented areas of Peyer's patch. Arrows in J and L indicate veins containing the latex dye. Scale bars represent 5 mm (A, B, G, H), 500 um (C-F), and 2 mm (I-L).

Copyright

This image is from Park SO, J Clin Invest 2009 Nov;119(11):3487-96 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:154620

Associated Alleles

Symbol	Name
Acvrl1^tm2.1Spo	activin A receptor, type II-like 1; targeted mutation 2.1, S Paul Oh
Gt(ROSA)26Sor^tm1(cre/ERT)Nat	gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Jeremy Nathans

Associated Genotypes

Allelic Composition	Genetic Background
Acvrl1^tm2.1Spo/Acvrl1^tm2.1Spo Gt(ROSA)26Sor^tm1(cre/ERT)Nat/Gt(ROSA)26Sor^+	involves: 129 * 129S1/Sv * 129X1/SvJ