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Caption | Hemorrhages and vascular malformation in the lungs and GI tract of tamoxifen (TM)-treated adult Acvrl1tm2.1Spo/Acvrl1tm2.1Spo Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+ (R26CreER/+;Alk12f/2f) mice. A, B. Gross morphology of heart and lungs of control and mutant mice 8 days after TM-treatment. Note enlarged mutant heart and lungs and hemorrhagic spots in the mutant lungs (B). C, D. Pulmonary arteries are visualized by latex dye injected via right heart. Note enlarged arteries and reduced perfusion to distal microvessels in the mutant lungs. E, F. Pulmonary veins (and bronchial arteries) by latex dye injected via left ventricle and left atrium. Photograph of control and mutant lungs was taken side by side. Mutant veins were significantly enlarged and showed roughness along the vessels indicating high permeability. G, H. Gross morphology of GI tract. Mutant guts were purplish and displayed signs of hemorrhages. A, appendix. I-L. Blood vessels of Peyer's patches in the ilium (I and J) and appendix (K and L) of control (I and K) and mutant (J and L) mice were visualized by the latex dye injection. Dotted circles indicate the represented areas of Peyer's patch. Arrows in J and L indicate veins containing the latex dye. Scale bars represent 5 mm (A, B, G, H), 500 um (C-F), and 2 mm (I-L). | ||||||
Copyright | This image is from Park SO, J Clin Invest 2009 Nov;119(11):3487-96 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:154620 | ||||||
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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