Phenotype Image Detail

Image

Caption

Uterine arteriovenous malformations (AVMs) in tamoxifen (TM)-treated adult Acvrl1^tm2.1Spo/Acvrl1^tm2.1Spo Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺ Alk1 mutants. Uterine blood vessels of control and mutant B) mice 8 days after TM treatment were visualized by the latex dye injection. Latex dye was confined in the feeding arteries in the controls (A), whereas it was found in both arteries and veins in the mutants (B). Note that latex dye in the venous vessels appeared as light blue. Scale bars represent 2 mm.

Copyright

This image is from Park SO, J Clin Invest 2009 Nov;119(11):3487-96 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:154620

Associated Alleles

Symbol	Name
Acvrl1^tm2.1Spo	activin A receptor, type II-like 1; targeted mutation 2.1, S Paul Oh
Gt(ROSA)26Sor^tm1(cre/ERT)Nat	gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Jeremy Nathans

Associated Genotypes

Allelic Composition	Genetic Background
Acvrl1^tm2.1Spo/Acvrl1^tm2.1Spo Gt(ROSA)26Sor^tm1(cre/ERT)Nat/Gt(ROSA)26Sor^+	involves: 129 * 129S1/Sv * 129X1/SvJ