Phenotype Image Detail

Image

Caption

A-X, H&E staining on sections of heads of Sox11^tm1.1Gan/Sox11^tm1.1Gan Tg(EIIa-cre)C5379Lmgd/0 (Sox11^Ella-Cre) embryos, shows the histology of developing palatal shelves. A-L, downward outgrowth of the palatal shelves shares similar features in mutants and their wild-type (Wt) littermates at E12.5 (A-C versus D-F) and E13.5 (G-I versus J-L). Palatal shelves elevate to the horizontal position above the tongue dorsum and contact each other in the midline at E14.5 in the Wt (M-O) but remain in a downward position in the mutant (P-R). In comparison with a completely formed secondary palate in the Wt (S-U), mutant mice still exhibit cleft palate with shelves in a downward position at E15.5 (V-X). T, tongue; Ps, palatal shelf. Scale bars = 200 um.

Copyright

This image is from Huang H, J Biol Chem 2016 Mar 25;291(13):7107-18 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:232434

Associated Alleles

Symbol	Name
Sox11^tm1.1Gan	SRY (sex determining region Y)-box 11; targeted mutation 1.1, Lin Gan
Tg(EIIa-cre)C5379Lmgd	transgene insertion C5379, Laboratory of Mammalian Genes and Development, Heiner Westphal

Associated Genotypes

Allelic Composition	Genetic Background
Sox11^tm1.1Gan/Sox11^tm1.1Gan Tg(EIIa-cre)C5379Lmgd/0	involves: 129S6/SvEvTac * C57BL/6 * FVB/N