Phenotype Image Detail

Image

Caption

Cell proliferation in the mandibular mesenchyme is reduced in Sox11^tm1.1Gan/Sox11^tm1.1Gan Tg(EIIa-cre)C5379Lmgd/0 (Sox11^Ella-Cre) embryos. A-H', immunohistochemistry shows a decrease in Cyclin D1 expression during mandible development in the mutant mandible at E11.5 (B versus A), E12.5 (D versus C), and E13.5 (F versus E). A significant reduction in Ki67 is evident in the mesenchyme (mc) in and surrounding Meckel cartilage at E13.5 (H versus G). G' and H' are enlarged pictures of the boxed areas in G and H, respectively. I, relative proliferation as number of Ki67-positive cells in the boxed area in the wild type (G) versus mutant (H). Arrows indicate the developing mandibular bone. Data are mean +/- S.D. of three independent samples. J-M, in situ hybridization showing the expression of Runx2 in the mandibular mesenchyme at E11.5 (J and K) and the mesenchyme surrounding Meckel cartilage at E13.5 (L and M).

Copyright

This image is from Huang H, J Biol Chem 2016 Mar 25;291(13):7107-18 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:232434

Associated Alleles

Symbol	Name
Sox11^tm1.1Gan	SRY (sex determining region Y)-box 11; targeted mutation 1.1, Lin Gan
Tg(EIIa-cre)C5379Lmgd	transgene insertion C5379, Laboratory of Mammalian Genes and Development, Heiner Westphal

Associated Genotypes

Allelic Composition	Genetic Background
Sox11^tm1.1Gan/Sox11^tm1.1Gan Tg(EIIa-cre)C5379Lmgd/0	involves: 129S6/SvEvTac * C57BL/6 * FVB/N