Phenotype Image Detail

Image

Caption

Sgpp2^tm1Rlp/Sgpp2^tm1Rlp (Sgpp2-/-) mice at 4 days after birth showed normal skin appearance and morphology (middle mouse) similar to wild-type (WT) mice (mouse on the left). In contrast, Sgpp1^{tm1(KOMP)Vlcg}/Sgpp1^{tm1(KOMP)Vlcg} (Sgpp1-/-) mice (mouse on the right) displayed severe ichthyosis.

This image is from Taguchi Y, J Biol Chem 2016 Jun 3;291(23):12029-38 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:235035

Associated
Alleles

Symbol	Name
Sgpp1^{tm1(KOMP)Vlcg}	sphingosine-1-phosphate phosphatase 1; targeted mutation 1, Velocigene
Sgpp1^{tm1(KOMP)Vlcg}	sphingosine-1-phosphate phosphatase 1; targeted mutation 1, Velocigene
Sgpp2^tm1Rlp	sphingosine-1-phosphate phosphatase 2; targeted mutation 1, Richard L Proia

Associated
Genotypes

Allelic Composition	Genetic Background
Sgpp1^{tm1(KOMP)Vlcg}/Sgpp1^{tm1(KOMP)Vlcg}	involves: C57BL/6NTac
Sgpp2^tm1Rlp/Sgpp2^tm1Rlp	B6.129S6-Sgpp2^tm1Rlp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24