Phenotype Image Detail

Image

Caption

The epithelial barrier of the choroid plexus is compromised in Pdcd6ip^tm1.2Adz/Pdcd6ip^tm1.2Adz (KO) mice. (a) Combination of brain fluorescence and bioluminescence images obtained 24 hours after intra-peritoneal injection of the dye Evans blue (n = 3). (b) 3D confocal analysis of wild-type (WT) and mutant whole-mount choroid plexus shows an increase intracellular flux of FITC-dextran into the mutant choroid plexus compared with the WT; yellow arrowheads indicate points of colocalization between FITC dextran (green) and ZO-1 (red) along the basolateral membrane of the mutant choroid plexus (n = 2).

Copyright

This image is from Campos Y, Nat Commun 2016 Jun 23;7():11876, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:238436

Associated Alleles

Symbol	Name
Pdcd6ip^tm1.2Adz	programmed cell death 6 interacting protein; targeted mutation 1.2, Alessandra d'Azzo

Associated Genotypes

Allelic Composition	Genetic Background
Pdcd6ip^tm1.2Adz/Pdcd6ip^tm1.2Adz	either: (involves: 129S1/Sv) or (involves: 129S1/Sv * C57BL/6)