Phenotype Image Detail

Image

Caption

Wdfy3^{tm1a(KOMP)Mbp}/Wdfy3^{tm1a(KOMP)Mbp} mice generated through gene targeting exhibit more severe neurodevelopmental defects than Wdfy3^disc/Wdfy3^disc mice. (a) Nissl stained coronal hemisections through the forebrains of wild-type (WT), heterozygous and homozygous lacZ newborn pups illustrate the malformations present in affected mutants. The yellow dashed line indicates the cortical length in the WT as measured from the corticostriatal boundary to the ventricular apex. The red dashed line indicates differences in cortical length present in the lacZ mutants. (b) Close-ups of cortical segments of lateral and dorsal positions demonstrate cortical thinning in lacZ mutants.

Copyright

This image is from Orosco LA, Nat Commun 2014;5():4692, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:225200

Associated Alleles

Symbol	Name
Wdfy3^tm1a(KOMP)Mbp	WD repeat and FYVE domain containing 3; targeted mutation 1a, Mouse Biology Program, UC Davis
Wdfy3^tm1a(KOMP)Mbp	WD repeat and FYVE domain containing 3; targeted mutation 1a, Mouse Biology Program, UC Davis

Associated Genotypes

Allelic Composition	Genetic Background
Wdfy3^tm1a(KOMP)Mbp/Wdfy3^tm1a(KOMP)Mbp	C57BL/6N-Wdfy3^tm1a(KOMP)Mbp