Phenotype Image Detail

Image

Caption

Absence of mucous (goblet) cells in tracheal and laryngeal submucosal glands in Spdef^tm1.1Cle/Spdef^tm1.1Cle mice. Tracheal/laryngeal glands in wild-type (WT) mouse are shown after H&E and Alcian blue staining. Distinct mucous cells (black arrowheads in A) and serous cells (red arrows in A and B) from WT mice are shown. Mucous cells were not detected in the submucosal glands of the mutant mice, although serous glands were present (B). Alcian blue staining was readily detected in submucosal glands of WT mice (arrow) (C) but rarely observed in submucosal glands of mutant mice (arrow) (D). Arrows indicate regions of higher magnification shown in inserts (C and D). Figures are representative of n = 3 individual mice of each genotype. Scale bars: 50 um.

Copyright

This image is from Chen G, J Clin Invest 2009 Oct;119(10):2914-24 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:154639

Associated Alleles

Symbol	Name
Spdef^tm1.1Cle	SAM pointed domain containing ets transcription factor; targeted mutation 1.1, Hans Clevers

Associated Genotypes

Allelic Composition	Genetic Background
Spdef^tm1.1Cle/Spdef^tm1.1Cle	involves: 129P2/OlaHsd