Phenotype Image Detail

Image

Caption

Impaired kidney development in Wnt4^tm1.1Svo/Wnt4^tm1.1Svo Tg(CAG-cre)13Miya/0 (Wnt4^c/c;CAGCre) fetuses. The urogenital system of E17.5 wild-type and Wnt4^tm1.1Svo/Wnt4^tm1.1Svo Tg(CAG-cre)13Miya/0 embryos, indicating pairs of kidneys, the adrenal gland, and the ovary. Early inactivation of Wnt4 function with CAGCre impairs kidney development and the kidneys remain rudimentary. Labels: a, adrenal gland; b, bladder; g, gonad; k, kidney. (b) Bar 100 uM.

Copyright

This image is from Shan J, Genesis 2009 Nov;47(11):782-8, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:154784

Associated Alleles

Symbol	Name
Tg(CAG-cre)13Miya	transgene insertion 13, Jun-ichi Miyazaki
Wnt4^tm1.1Svo	wingless-type MMTV integration site family, member 4; targeted mutation 1.1, Seppo Vainio

Associated Genotypes

Allelic Composition	Genetic Background
Wnt4^tm1.1Svo/Wnt4^tm1.1Svo Tg(CAG-cre)13Miya/0	involves: 129/Sv * C57BL/6