Phenotype Image Detail

Image

Caption

Elavl1^tm1.1Thla/Elavl1⁺ (Elavl1+/-) mice have increased sensitivity to whole-body irradiation. (A) A schematic of wild-type (Elavl1+/+; WT) and heterozygous mutant mice exposed to radiation. (B) Total cell number in bone marrow (BM), spleen, and thymus in nonirradiated WT and mutant mice (n = 3). (C) H&E stain of bone and spleen tissue sections from WT and mutant mice before and after irradiation. Original magnification, 10 (spleen); 40 (BM). Scale bar: 20 um (BM); 100 um (spleen). (D) Total number of cells isolated from BM, spleen, and thymus of irradiated WT and mutant mice (n >/= 5). Horizontal bars indicate mean of data points, and each dot represents an analyzed mouse (B and D).

Copyright

This image is from Ghosh M, J Clin Invest 2009 Dec;119(12):3530-43 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:155109

Associated Alleles

Symbol	Name
Elavl1^tm1.1Thla	ELAV like RNA binding protein 1; targeted mutation 1.1, Timothy Hla

Associated Genotypes

Allelic Composition	Genetic Background
Elavl1^tm1.1Thla/Elavl1^+	involves: 129S1/Sv