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Caption | Hyperplasia and hypertrophy of Ptentm1Hwu/Ptentm1Hwu Tg(Tyr-cre)1Lru/0 (HM) enteric neuronal cells (ENCs). (A) Transverse sections of wild-type (WT) and HM colons at P15: H&E staining, immunostaining with antibodies directed against TUJ1, NF, and Syn. Note that HM ganglia were bigger than WT ganglia. Scale bar: 50 um. (B) Transverse sections of WT, heterozygous (HT), and HM colons at P15. The surface of enteric nervous system (ENS) cells was estimated using ImageJ software. Note that HM ENS cells are twice as big as WT and HT ENS cells. ***P < 0.001. Scale bar: 25 um. (C) Transverse sections of WT, HT, and HM small intestine and colon in the proximal, middle, and distal parts immunostained with TUJ1 antibody and counter-stained with DAPI. The number of DAPI+ and TUJ1+ cells was determined in each compartment and plotted. Note that the number of DAPI+ and TUJ1+ cells is higher in the colon than in the small intestine. Scale bar: 25 um. Dotted lines enclose ENS. Error bars represent mean + SEM. | ||||||
Copyright | This image is from Puig I, J Clin Invest 2009 Dec;119(12):3586-96 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:155110 | ||||||
Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/21/2024 MGI 6.24 |
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