Phenotype Image Detail

Image

Caption

Pten^tm1Hwu/Pten^tm1Hwu Tg(Tyr-cre)1Lru/0 (HM) mice present hyperpigmentation. Macroscopic and microscopic views of WT (A, C, E, E', G, G', I) and HM (B, D, F, F', H, H', J) mice. HM tails (B), pinnae (D), paws (F, F') and olfactory bulbs (J) in P15 HM mice were more pigmented than in P15 WT mice. Transverse sections of WT (G, G') and HM (H, H') skin show that HM hair follicles were more pigmented than WT. Scale bar (E-F' and I,J): 1 mm and scale bar (G-H'): 50 um. Pten^tm1Hwu/Pten^tm1Hwu or Pten^tm1Hwu/Pten⁺ are considered as WT.

Copyright

This image is from Puig I, J Clin Invest 2009 Dec;119(12):3586-96 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:155110

Associated Alleles

Symbol	Name
Pten^tm1Hwu	phosphatase and tensin homolog; targeted mutation 1, Hong Wu
Tg(Tyr-cre)1Lru	transgene insertion 1, Lionel Larue

Associated Genotypes

Allelic Composition	Genetic Background
Pten^tm1Hwu/Pten^tm1Hwu Tg(Tyr-cre)1Lru/0	B6.Cg-Pten^tm1Hwu Tg(Tyr-cre)1Lru