Phenotype Image Detail

Image

Caption

Pten^tm1Hwu/Pten^tm1Hwu Tg(Tyr-cre)1Lru/0 (HM) mice present hyperplasia of the enteric glial cells. (A) Transverse sections of wild-type (WT) and HM P15 colons were immunostained for GFAP, and double-immunostained for GFAP and PTEN. Merged immunofluorescence is shown for WT and HM. Note that GFAP-positive cells produce PTEN in WT colon, but do not contain any PTEN protein in the HM colon. Scale bar for immunohistochemistry: 50 um; scale bar for immunofluorescence: 25 um.

This image is from Puig I, J Clin Invest 2009 Dec;119(12):3586-96 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:155110

Associated
Alleles

Symbol	Name
Pten^tm1Hwu	phosphatase and tensin homolog; targeted mutation 1, Hong Wu
Tg(Tyr-cre)1Lru	transgene insertion 1, Lionel Larue

Associated
Genotypes

Allelic Composition	Genetic Background
Pten^tm1Hwu/Pten^tm1Hwu Tg(Tyr-cre)1Lru/0	B6.Cg-Pten^tm1Hwu Tg(Tyr-cre)1Lru

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