Phenotype Image Detail

Image

Caption

Morphometric analysis of islet size. Representative sections of pancreas immunostained with anti-beta catenin antibody to visual beta cell and islet size in Rps6kb1^tm1Gtho/Rps6kb1^tm1Gtho (S6K1-/-), Tg(Ins2-Akt1*)3Mbb/0 (MyrAkt1), and Tg(Ins2-Akt1*)3Mbb/0 Rps6kb1^tm1Gtho/Rps6kb1^tm1Gtho (MyrAkt1;S6K1-/-) mice.

Copyright

This image is from Alliouachene S, J Clin Invest 2008 Nov;118(11):3629-38 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:144599

Associated Alleles

Symbol	Name
Rps6kb1^tm1Gtho	ribosomal protein S6 kinase, polypeptide 1; targeted mutation 1, George Thomas
Tg(Ins2-Akt1*)3Mbb	transgene insertion 3, Morris J Birnbaum

Associated Genotypes

Allelic Composition	Genetic Background
Rps6kb1^tm1Gtho/Rps6kb1^tm1Gtho	B6.129P2-Rps6kb1^tm1Gtho
Tg(Ins2-Akt1*)3Mbb/0	B6.Cg-Tg(Ins2-Akt1*)3Mbb
Rps6kb1^tm1Gtho/Rps6kb1^tm1Gtho Tg(Ins2-Akt1*)3Mbb/0	B6.Cg-Rps6kb1^tm1Gtho Tg(Ins2-Akt1*)3Mbb